Mechanism of Action

How Tirzepatide Works

Tirzepatide is a first-in-class dual GIP/GLP-1 receptor agonist. Understanding how it works helps you make informed decisions about your treatment.

The Science Behind Tirzepatide

Dual Receptor Activation

Tirzepatide activates both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors. This dual action is what sets it apart from other treatments that target only one receptor.

Appetite Regulation

By mimicking natural incretin hormones, Tirzepatide slows gastric emptying and signals satiety to the brain. This reduces hunger and helps you feel fuller for longer after meals.

Blood Sugar Control

The medication enhances insulin secretion when blood sugar is elevated and suppresses glucagon release. This helps maintain healthy blood glucose levels throughout the day.

Metabolic Improvement

Beyond weight loss and blood sugar control, Tirzepatide improves overall metabolic function including lipid profiles, blood pressure, and inflammatory markers.

The Injection Process

Tirzepatide is administered as a once-weekly subcutaneous injection. Here's what to expect:

Injection Sites

Abdomen, thigh, or upper arm. Rotate injection sites each week to reduce irritation.

Frequency

Once weekly, on the same day each week. Can be taken with or without food, at any time of day.

Pre-filled Pen

Comes in a single-dose pre-filled pen that is easy to use. The needle is thin and most patients report minimal discomfort.

Storage

Store in the refrigerator (36°F to 46°F). May be kept at room temperature for up to 21 days if needed.

Dosing Schedule

Tirzepatide follows a gradual dose-escalation schedule to help minimize gastrointestinal side effects.

2.5 mg

Weeks 1-4

Starting dose to minimize side effects

5 mg

Weeks 5-8

First therapeutic dose increase

7.5 mg

Weeks 9-12

Intermediate dose if needed

10 mg

Weeks 13-16

Higher dose for additional effect

12.5 mg

Weeks 17-20

Continued escalation if tolerated

15 mg

Weeks 21+

Maximum dose

Your healthcare provider will determine the appropriate dosing schedule based on your individual response and tolerability.

Want to Learn About the Benefits?

Discover the clinical results and health improvements associated with Tirzepatide treatment.

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